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  • OCTOBER 2020 Issue has been successfully launched on 1 October 2020.

Abstract

AUTO IMMUNE DISODERS EMERGING TRENDS FROM RA TO MCTD - A CLINICAL OVERVIEW – WITH AYURVEDIC TREATMENT MODALITIES.

Dr. Satender Tanwar*, Dr. Midhun Mohan, Dr. Sneha Makhane, Dr. Om Chitte, Dr. Shailaja S. V. and Dr. Kiran M. Goud

ABSTRACT

One of the classically accepted features of the immune system is the capacity to distinguish self from non self. Recognition of self plays a important role in shaping both the B cells and T cells repertoires of the immune receptors and plays a essential role in the recognition of nominal antigens by T cell, the development of potentially harmful immune responses to the self antigens is, in general precluded. Since Ehrlich first postulated the existence of mechanism to prevent the generation of self – reactivity in 1900, ideas concerning the nature of this inhibition have developed in parallel with the progressive increase in understanding of immune system. Burnets clonal selection theory included the idea that the interaction of lymphoid cells with their specific antigens during fetal or early postnatal life would lead to elimination of such ―forbidden clones.‖ Looking back to decade ago very rare to find the cases of MCTD but comparing the presenting scenarios the more patients are presenting with not only the RA but also some other features of the MCTD collectively. This was the change observed in the population due to the change in the dietery and life style modifications which is presently contributing as the major part of the disease aetiology and major burden of the disease causing factors. Treatment of the autoimmune disease can focus on suppressing the induction of auto immunity, restoring normal regulatory mechanism, or inhibiting the effectors mechanism.

Keywords: Autoimmune, rheumatoid arthritis, Mixed connective tissue disorders, Mimicry.


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