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Abstract

EVALUATION THE ACTIVITY OF CHLOROFORM EXTRACT OF SOLANUM NIGRUM ON NON HODGKIN LYMPHOMA CELL LINE (SR), RAT EMBRYO FIBROBLAST CELL LINE (REF) AND HUMAN LYMPHOCYTES IN VITRO

Huda Kh. A*., Saadi Kh., Nahi Y.Yaseen

ABSTRACT

Objective: The present study was designed to evaluate in vitro the cytotoxic activity of chloroform fruit extract (mature-black, and immature- green) of Solanum nigrum L. against Non Hodgkin Lymphoma (SR) Cell Line and Rat Embryo Fibroblast (REF) Cell Line. In addition, involves their effects on the division of the normal human lymphoid cells (Mitotic Index IM). Methods: The fruits of S, nigrum were prepared to extract by chloroform with serial dilution in concentrations (312.5, 625, 1250, 2500, 5000, and 10000) μg/mL using MTT assay. Results: The results show existence of clear significant (P≤0.05) cytotoxic effect of Solanum nigrum chloroform extract on SR cancer cell line. The green berries were more effective. The highest inhibition rate was 90.05% in concentration 10000μg/mL and IC50 was 669.27μg/mL for exposures time 72hr. While on REF cell line, the green berries extract was the highest inhibition rate54% in concentration 10000μg/mL and IC50 was 7628.1μg /mL for exposures time 72hr.The crude extracts did not have the ability to motivate the cell division of the lymphoid cells. Mitotic Index. Conclusions: Chloroform extract of green berries show greater activity on SR cancer cell line and little activity on REF cell line.No effect on motivate or stopping human lymphocyte cells.

Keywords: Solanum nigrum, Non Hodgkin Lymphoma, Rat Embryo Fibroblast.


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