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Abstract

ANALYSIS OF ALLELES FREQUENCIES AND CANDIDATE GENES FOR HYPERTENSION OF THE POPULATION OF THE CITY ROSTOV-ON-DON

Thamer Mouhi Jasiem*

ABSTRACT

Objective: The Study was designed to investigate The frequencies of 2 alleles candidate genes associated with risk of development of hypertension disease. Polymorphic alleles of I/D gene ACE (Angiotensin-converting enzyme) and A1166C gene AGTR1– (Angiotensin II type 1 receptor) were investigated between inhabitants of Rostov-on-Don. Methods: Isolation of DNA from leucocytes using the whole blood reagent "DNA express blood". To isolate the DNA from peripheral blood using a commercial reagent kit DNA- Express, which is intended to isolate the DNA from various natural materials. There were about 43 people surveyed patients with hypertension. The control group accounted for 20 DNA samples of healthy individuals without any signs of vascular lesions. Results: For patients with hypertension in ACE gene showed an increased risk of hypertension for genotypes ID ACE / AA AGTR1 and II ACE / AC AGTR1 (χ ² = 1.696 , p = 0.1928). Thus, it was found that the combination of one genotype allelic variants of two genes that increases the risk of hypertension. Conclusion: When analyzing the distribution of alleles and genotypes of this polymorphic marker we found statistically significant differences. It was shown that the carriers of allele I and genotype ID have an increased risk of developing hypertension, while allele carriers D - reduced risk. Thus, polymorphic marker I/D ACE gene is associated with the development of hypertension among residents of Rostov region.

Keywords: ACE (Angiotensin-converting enzyme), AGTR1 (Angiotensin II type 1 receptor), hypertension.


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