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Abstract

PHYTOCHEMICAL SCREENING AND ANTI-DIABETIC EFFICACY OF STEM OF HIPTAGEBENGHALENSIS (L) KURZ

ShehlaUnaizaHridi*, NafisaFerdous, FakharUddinMajumder, Dr.JMA Hannan

Department of Pharmacy, North South University, Plot -15, Block- B, Bashundhara R/A, Dhaka, Bangladesh.

ABSTRACT

Our present studies were focused on the phytochemical study and probable anti-diabetic activity ofthe stem of HiptageBenghalensis in laboratory animals and the statistical significance of such effect. Qualitative phytochemical analysis of ethanol extract of Hiptage Benghalensis for identification of steroid, carbohydrate, flavonoid, alkaloid, tannins, phenol, mangiferin and terpenoids compounds were carried out using proper reagents. The stem extract was subjected to anti-diabetic study through six segment method which was performed to assess the amount of sucrose remaining in the GIT at six different positions. The amount of sucrose unabsorbed in different GIT segments were evaluated in control rats vs. rats fed with 500mg/kg extract at 30 minutes, 1hour,2hour and 4 hour. The phytochemical screening of ethanol extract of Hiptage Benghalensis exhibited the presence of several phytochemical components including the presence of flavonoids and terpenoids which have been reported to possess anti-diabetic properties. The extract caused a significant (p<0.05), dose dependent inhibition of glucose absorption and showed hypoglycemic effects in Long-Evans rats weighing from 80-200 gm. The anti-diabetic effects were estimated by measuring the amount of glucose in the samples collected after the experiment. In conclusion, these observations provide evidence and possible mechanisms of action for the anti-diabetic properties of stem of HiptageBenghalensis claimed in Ayurveda medicine.

Keywords: Anti-Diabetic, HiptageBenghalensis, Hypoglycemic,Glucose, Phytochemical.


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