Abstract

IN-VIVO, ANTI-HYPERGLYCEMIC AND ANTI-HYPERLIPIDEMIC ACTIVITY OF ANNONA SQUAMOSA (Linn.) LEAVES, COLLECTED FROM SOUTHERN ODISHA

Arun Kumar Panda¹*, Mangala Charan Das², Prasana Kumar Panda³, Suman Kumar Mekap³, Saumya Ranjan Pani³

ABSTRACT

The present study was aimed to evaluate the anti-hyperglycemic and anti-hyerlipidemic activity of ethanolic extracts of Annona squamosa (Linn.) leaves (AS), collected from southern Odisha. Alloxan induced, Streptozotocin-Nicotinamide (STZ-NA) induced diabetic models and Triton(W111) induced hyerlipedemic models in rats were used in the said experiment. Treatment with AS (400 mg/kg) to alloxan treated rats for 10 days significantly (p<0.001) attenuated the blood glucose level (141.30 ± 11.56 mg/dl) of test animals when compared to alloxan control (293.16 ± 7.32 mg/dl). Similarly, in STZ-NA induced diabetic model, significant (p<0.001) reduction in blood glucose level (152.61 ± 6.83 mg/dl) in test animals were observed, following the treatment of AS (400 mg/kg) for 28 days. In Triton (W1339) induced hyperlipidemia (48 hour model), AS (400 mg/kg) treatment exhibited significant (p<0.001) attenuation in serum total cholesterol (70.92 ± 3.46 mg/dl), triglyceride (125.67 ± 6.54 mg/dl) and LDL (10.42 ± 6.77 mg/dl) with significant (p<0.05) elevation in serum HDL (35.36 ± 5.32 mg/dl) levels. Statistical significance of data was assessed by Oneway ANOVA followed with Tukey-Kramer Multiple comparison between different groups. The data obtained from the study suggested, the anti-diabetic and lipid lowering activities of Annona squamosa (Linn.) leaves.

Keywords: antidiabetic, anti-hyperlipidemic, custard apple.