Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS AUGUST ISSUE PUBLISHED
  • AUGUST 2020 Issue has been successfully launched on 1 August 2020.

Abstract

IN-VIVO, ANTI-HYPERGLYCEMIC AND ANTI-HYPERLIPIDEMIC ACTIVITY OF ANNONA SQUAMOSA (Linn.) LEAVES, COLLECTED FROM SOUTHERN ODISHA

Arun Kumar Panda1*, Mangala Charan Das2, Prasana Kumar Panda3, Suman Kumar Mekap3, Saumya Ranjan Pani3

1Om Sai College of Pharmacy and Health Sciences, Gopalpur -761002, Ganjam, Odisha.
2NRI Medical College Mangalagiri Road, Chinakakani-522503, Guntur, AP
3University Department of Pharmaceutical Sciences, Utkal University, Vanivihar Bhubaneswar-751004 Odisha, India.

ABSTRACT

The present study was aimed to evaluate the anti-hyperglycemic and anti-hyerlipidemic activity of ethanolic extracts of Annona squamosa (Linn.) leaves (AS), collected from southern Odisha. Alloxan induced, Streptozotocin-Nicotinamide (STZ-NA) induced diabetic models and Triton(W111) induced hyerlipedemic models in rats were used in the said experiment. Treatment with AS (400 mg/kg) to alloxan treated rats for 10 days significantly (p<0.001) attenuated the blood glucose level (141.30 ± 11.56 mg/dl) of test animals when compared to alloxan control (293.16 ± 7.32 mg/dl). Similarly, in STZ-NA induced diabetic model, significant (p<0.001) reduction in blood glucose level (152.61 ± 6.83 mg/dl) in test animals were observed, following the treatment of AS (400 mg/kg) for 28 days. In Triton (W1339) induced hyperlipidemia (48 hour model), AS (400 mg/kg) treatment exhibited significant (p<0.001) attenuation in serum total cholesterol (70.92 ± 3.46 mg/dl), triglyceride (125.67 ± 6.54 mg/dl) and LDL (10.42 ± 6.77 mg/dl) with significant (p<0.05) elevation in serum HDL (35.36 ± 5.32 mg/dl) levels. Statistical significance of data was assessed by Oneway ANOVA followed with Tukey-Kramer Multiple comparison between different groups. The data obtained from the study suggested, the anti-diabetic and lipid lowering activities of Annona squamosa (Linn.) leaves.

Keywords: antidiabetic, anti-hyperlipidemic, custard apple.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More