Abstract

ULVA FASCIATA NANOPARTICLES CHARACTERIZATION AND ITS ANTICANCER ACTIVITY

Abirami R. G.* and Kowsalya S.

ABSTRACT

Seaweeds are non-flowering marine macro algae which are grown in wide spectra. The edible green seaweed Ulva fasicata shows potent therapeutic value and it is used as nanoparticle agent in cancer therapy. Synthesis of biological nanoparticles is physiologically toxic free with more effective in the treatment of cancer. Hence Ulva fasicata was developed as nanoparticles to treat against DAL cancer cell line in albino mice. Ulva fasciata nanoparticles were developed in low cost and most potential method and studied for its characterization like size, morphology and active compounds using SEM, FTIR and AFM. After confirmation of nanoparticles were exploring for its anticancer activity against cancer cells. The characterization study showed that the developed nanoparticles are spherical in shape with polydispersed and few clusters were seen in the SEM micrograph. AFM image shows theparticles were in the range of 50 to 190nm. FT-IR image depict majority of compounds were phenols and amines. Those nanoparticles significantly increased the life span of cancer treated mice, decrease the cancer cell count and reverse the liver functional enzymes level thus it’s proved an efficient anticancer activity against cancer cells.. Thus it shows potent anticancer activity when compare to its extract and the techniques used here was less expensive, low-energy way to make stable and all-natural nanoparticles.

Keywords: Ulva fasciata, Nanoparticles, Charaterization, SEM, AFM, FTIR.