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Abstract

EFFECT OF ASIAN HONEYBEE (APIS CERANA) VENOM ON DYNAMICS OF BLOOD BIOCHEMICAL PARAMETERS OF HEPATIC FUNCTION IN ALBINO RATS

Shoeb Ahmad*1, G. G. H. A. Shadab1 and Ravi Kant Upadhyay2

1Cytogenetics and Molecular Toxicology Laboratory, Section of Genetics, Department of Zoology, Aligarh Muslim University, Aligarh-202002 (UP), India.
2Molecular Biology Laboratory, Department of Zoology, Deen Dayal Upadhyay Gorakhpur University, Gorakhpur-273009 (UP), India.

ABSTRACT

Honeybee stings are common and frequent threat in tropical and subtropical regions of the globe, where fatal envenoming due to their massive attacks has been documented. Majority of bee toxins are cytotoxins and primarily target to liver. Further, liver plays very important role in mammalian metabolism, so that any change in liver systematics will definitely affect complete metabolism of an animal. The present investigation has been emphasized on dynamics of some vital liver enzymes in circulation. The sub-lethal venom doses (1/4 and 1/2 LD50) has induced unenviable increase in level of serum alanine amino transferase (ALT), aspartate amino transferase (AST), alkaline phosphatase (ALP) and gamma-glutamyl transpeptidase (GGT). These enzymes provide functional support to liver in maintaining metabolic equilibrium. However, presence of liver functioning enzymes in circulation is the signal of massive damage of hepatic cells resulting in certain systemic reactions.

Keywords: Apis cerana, honeybee venom, liver enzymes, hepato-toxicity.


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