WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

A REVIEW ON QUANTIFICATION OF AN ANTICANCER DRUG- IMATINIB BY LIQUID CHROMATOGRAPHY COUPLED TO MASS SPECTROMETRY (LC-MS) TECHNIQUE

Hafiz A. Makeen, Mohammed Al-Bratty*, Md Shamsher Alam

ABSTRACT

Imatinib mesylate is used in treating chronic myelogenous leukemia (CML), gastrointestinal stromal tumors (GISTs) and a number of other malignancies. It is the first member of a new class of agents that act by inhibiting particular tyrosine kinase enzymes, instead of non-specifically inhibiting rapidly dividing cells. Therapies with imatinib have shown significant inter-individual variability in pharmacokinetics, demanding a need for Therapeutic Drug Monitoring (TDM) in order to achieve an optimal response in CML therapy and to minimize adverse side effects. LC-MS has widely been applied as a reliable technique for quantification of imatinib in human plasma. The linearity of the LC-MS method was evaluated over the imatinib concentration range of 30 – 10000 ng/mL in human plasma with correlation coefficient (R2) of ≥ 0.999. The recoveries determined at low, medium and high concentration levels varied from 95 – 107 % and within the acceptable limits. Validated method has proved to be linear, accurate, precise, and robust, it is suitable for pharmacokinetic assays, such as bioavailability and bioequivalence, and is being successfully applied in routine therapeutic drug monitoring in the hospital service.

Keywords: Imatinib, Liquid Chromatography, Plasma, LC-MS/MS, Fragmentation.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More