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Abstract

ANTIMICROBIAL, ANTIOXIDANT AND ANTI ?-GLUCOSIDASE ACTIVITIES OF THE LEAF EXTRACT FROM MUSSAENDA ROXBURGHII HOOK. F. (RUBIACEAE)

Debasish Maiti1* Bhaskar Bhattacharjee1, Ashish Kumar Singha1, Ranjit Ghosh2, and Utpal Chandra De2.

1Department of Human Physiology, Tripura University, Suryamaninagar, Tripura, India.
2Department of Chemistry, Tripura University, Suryamaninagar, Tripura, India.

ABSTRACT

Context: The genus Mussaenda (Rubiaceae) includes 200 species distributed in hilly tracks of north eastern India and in tropics of the old world. Mussaenda roxburghii Hook. f. mainly grown in Tripura and other north eastern states of India has been used as traditional medicine. Objectives: The objective of this study was to evaluate in vitro antimicrobial, antioxidant and anti-α-glucosidase activities of the leaves extract from Mussaenda roxburghii. Methods: Antimicrobial assay was done by disc diffusion technique using six human pathogenic bacteria, Shigella dysenteriae 1, Vibrio cholerae non.0139(L4), Vibrio cholerae non.0139(CSK6669), Streptococcus pneumoniae, Staphylococcus aureus and Escherichia coli. In vitro antioxidant potential was studied using DPPH (1,1-diphenyl-2-picryl hydrazyl) and superoxide radical scavenging property with Butylated Hydroxy Anisole (BHA) and Ascorbic acid as positive control, respectively. In vitro α-glucosidase (E.C No.3.2.1.20) inhibitory activity was determined using Acarbose as positive control. Results: Among the two fractions, maximum antimicrobial activity was against V. cholerae non.0139(CSK6669) at 500 μg/disc with n- butanol fraction and with chloroform fraction it was against S. aureus and E. coli at 1 mg/disc concentration. At 100μg/ml concentration both n-butanol and chloroform fractions showed significant antioxidant activity against DPPH and superoxide radicals. Both the fractions also exhibited moderate inhibition of α-glucosidase activity at 500 μg/ml of n-butanol fraction and 250 μg/ml of chloroform fraction. Conclusion: The results indicated that leaf extract of Mussaenda roxburghii has antimicrobial, antioxidant and α-glucosidase inhibitory activity. Phytochemical investigation of these extracts is needed to find out potent antimicrobial, anti-diabetic phytochemicals for their use as herbal drugs.

Keywords: leaf extract, antimicrobial, antioxidant, antidiabetic, butanol, Mussaenda roxburghii.


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