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Abstract

CHEWING GUM BASED NOVEL DRUG DELIVERY SYSTEM FOR ANTIHISTAMINIC DRUG

*Tanvee M. Deshpande 1, Ramesh G. Katedeshmukh 1, Seema Trivedi 2

1Department of Pharmaceutics, SCES’s Indira College of Pharmacy, Tathawade, Pune- 411033, India.
2DGM- Technical, Divakar Chemicals Ltd., Goregaon East, Mumbai-400063, India.

ABSTRACT

The present work is focused on the development and characterization of Chlorpheniramine maleate medicated chewing gum as an intra-oral drug delivery system. The chewing gums were prepared using Health in Gum grade-02(HiG-02) as a directly compressible gum base developed by Cafosa. A total of six formulations were prepared and divided into two sets. In one set of experiment drug was added in solution form named as WG series while in other set drug was added as a dry powder named as DC series. Each set consisted of three formulations with concentration of HiG-02 as 65%, 75% and 85% respectively so as to study its effect on the drug release profile and chewing property. The formulations were evaluated for granule properties, in-process parameters and finished product parameters. Among the six formulations WG-2 emerged as the best formulation with percent release of 97.02±1.296% and optimum chewing property. Accelerated stability studies were conducted on blister packed WG-2 batch for period of three months at 40 ± 2o C/75 ± 5% RH.

Keywords: Medicated Chewing Gum, Chlorpheniramine maleate (CPM), Health in Gum Grade-02 (Hig-02), Erweka DRT-6 Chewing Apparatus, Masticatory Property.


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