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Abstract

A RESEARCH ON FORMULATION AND EVALUATION OF FLOATING MICROSPHERES OF GLIMEPIRIDE

Mohit Sharma*, Ajay Bilandi and Mahesh Kumar Kataria

ABSTRACT

The Glimepiride is a drug of choice for the physician for Non Insulin Dependent Diabetes (NIDD). The drug in oral conventional dosage form has the dosage regime of three times a day. The repeated administration in a day may cause non compliance by the patients. Thus, it is emphasized to prolong/sustain release delivery of the drug to avoid repeated administration. The study comprises that floating microsphere of Glimepiride, model drug, may increase the gastric residence time. The floating microspheres are prepared by the emulsification solvent diffusion technique using polymers Ethyl cellulose, Eudragit RS100 and Guargum in different ratio 1:1,1:2,1:3,2:2 2:3. The formulated microsphere was evaluated for the percentage yield, percentage encapsulation efficiency, percentage buoyancy and in vitro drug release. Floating microspheres prolong the release of the drug and gastric residence time, release almost 76% drug with in 24hrs.

Keywords: Glimepride, Floating microspheres, Effect of polymers, Solvent Evaporation method.


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