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Abstract

DIFFERENT AYURVEDIC DOSAGE FORMS OF DASHAMOOLA POSSESS VARIED ANTI-INFLAMMATORY ACTIVITY

Bhagyashri Nagarkar1, Suresh Jagtap1*, Aarti Narkhede1, Pallavi Nirmal1, Nayana Pawar1, Aniket Kuvalekar1, Omkar Kulkarni1 and Abhay Harsulkar2

1Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth Deemed University, Pune Satara Road, Pune- 411 043, Maharashtra, India
2Department of Pharmaceutical Biotechnology, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Erandwane, Pune- 411 038, Maharashtra, India.

ABSTRACT

Dashamoola is a polyherbal preparation derived from roots of ten plants. It is used in Indian traditional medicine for different ailments especially for inflammation using various dosage forms. The objective of this study was to evaluate antioxidant and anti-inflammatory activity of selected dosage forms of Dashamoola. Dosage forms viz. Arishta of Dashamoola where as Churna, Kalpa and Kwatha of Dashamoola, Brihatpanchamoola and Laghupanchamoola were investigated. Antioxidant activity was assayed by using DPPH free radical scavenging activity, total antioxidant activity by FRAP, anti-lipid peroxidation activity and nitric oxide scavenging potential whereas anti-inflammatory potential was checked by Carrageenan induced rat paw edema model. Dashamoola Kwatha (341.9210.36 μg/ml), Brihatpanchamoola Kwatha (1754.26299.87 μg/ml), Dashamoola Churna (149.2461.09 μg/ml) exhibited highest activity with lowest IC50 values for free radical scavenging, anti-lipid peroxidation and nitric oxide scavenging respectively. Laghupanchamoola Kwatha showed highest concentration of antioxidants (0.2780.003 μg/ml) and thereby exhibited highest total antioxidant activity. In case of carrageenan induced rat paw edema model, Dashamoola Kwatha at a dose of 1.8 ml/kg bw produced the significant reduction in paw edema (44.29%) followed by Dashamoolarishta (43.35%) at a dose of 0.9 ml/kg bw. Almost all selected dosage forms of Dashamoola displayed antioxidant as well as anti-inflammatory activity at different levels. Dashamoola Kwatha and Dashamoolarishta showed consistent and significant results. The results of present investigation suggest that Kwatha and Arishta are the most suitable dosage forms of Dashamoola for the treatment of inflammatory disorders. These findings also support the traditional use of specific dosage forms of drug.

Keywords: Anti-inflammatory, Antioxidant, Comparative efficacy, Dashamoola, Dosage forms, Traditional medicine.


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