Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS AUGUST ISSUE PUBLISHED
  • AUGUST 2020 Issue has been successfully launched on 1 August 2020.

Abstract

BIOCOMPATIBLE POLYMER GUM ACACIA COATED BOVINE SERUM ALBUMIN (BSA) NANOPARTICLES INCORPORATED AZITHROMYCIN (P-BSA NP-AZ) PREPARATION FOR THE IMPROVED ANTI BACTERIAL ACTIVITY AGAINST HUMAN PATHOGENIC BACTERIA

*S.Karthick Raja Namasivayam, A.T.George Robin, R.S.Arvind Bharani, L.Vigneshwaraprakash and J.M.Vivek

Department of Biotechnology, Sathyabama University, Chennai, Tamil Nadu, India.

ABSTRACT

Improved anti bacterial activity of biocompatible polymer coated bovine serum albumin nanoparticles incorporated azithromycin was evaluated against human pathogenic bacteria. Optimization of f BSA nanoparticles was studied with various parameters such as pH, Ethanol to BSA ratio and crosslinking time. Anti bacterial study was carried out with the nano conjugate against clinical isolate of human pathogenic bacteria Pseudomonas aeruginosa and Staphylococcus aureus adopting well diffusion assay. Determination of minimum inhibitory concentration was studied by broth dilution method.The optimal pH was found to be 8.0, the ethanol to albumin ratio was found to be 4:1 and cross linking time of 8hrs which gives the higher yield of BSA nanoparticles..The Nanospheres thus formed were characterized using scanning electron microscope which showed a particle size of nanosphere in the range of 145nm. Anti bacterial study was carried out with the nano conjugate against clinical isolate of human pathogenic bacteria,Pseudomonas aeruginosa and Staphylococcus aureus. All the tested bacteria were susceptible to the tested concentration of nano drug conjugate and the anti bacterial activity was increased with minimum 10 to maximum 20mm of zone of inhibition.Dsistinct increase in anti bacterial activity of polymer coated BSA nano drug conjugate against human pathogenic bacteria would suggests the possible utilization of polymer coated BSA nanoparticles incorporated azithromycin against pathogenic bacteria.

Keywords: bovine serum albumin nanoparticles, azithromycin,gum acacia, pathogenic bacteria,nano drug conjugate,improved activity.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More