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  • WJPPS AUGUST ISSUE PUBLISHED
  • AUGUST 2020 Issue has been successfully launched on 1 August 2020.

Abstract

SYNTHESIS, CHARACTERISATION AND ANTIMICROBIAL EVALUATION OF NOVEL COMPOUNDS OF 1-(2,5-DI FLUORO BENZOYL)-4-(2-PHENYLHYDRAZONO)-3-(((5-(4- (TRIFLUOROMETHYL)PHENYL)-1,3,4-OXADIAZOL-2- YL)METHYL)AMINO)-1H-PYRAZOL-5(4H)-ONE

K. Sudhakar Babu, M. Swarna Kumari*, L.K. Ravindhranath, J. Latha, V. Prabhakar

ABSTRACT

New novel derivatives of 1-(2,5-difluorobenzoyl)-4-(2- phenylhydrazono)-3-(((5-(4(trifluoromethyl) phenyl)-1,3,4-oxadiazol- 2-yl) methyl)amino)-1H-pyrazol-5(4H)-one (4a-g) were prepared by condensation of 2-((1-(2,5-difluorobenzoyl)-5-oxo-4-(2-pheny l hydrazono )-4,5-dihydro-1H-pyrazol-3-yl)amino)acetohydrazide (3a). The synthon (3) was obtained by the condensation of ethyl 2-((1-(2,5- difluorobenzoyl)-5-oxo-4-(2-phenylhydrazono)-4,5-dihydro-1Hpyrazol- 3-yl)amino)acetate (2). The synthons (2) was obtained by the reaction 3-amino-1-(2,5-difluorobenzoyl)-4-(2-phenylhydrazono)-1Hpyrazol- 5(4H)-one (1). The newly synthesized compounds were characterized by IR, 1H-NMR, 13C-NMR, mass spectra & Elemental analysis. The newly synthesized compounds were screened for their Biological activity.

Keywords: 1, 3, 4-oxadiazoles, Antibacterial and Antifungal activity, Synthesis.


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