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Abstract

SYNTHESIS, CHARACTERISATION AND BIOLOGICAL EVALUATION OF 3,4-DIHYDROPYRIMIDIN-2(1H)-ONES

Kolluri Ramesh* and P. Thriveni

ABSTRACT

An efficient synthesis of 3,4-dihydropyrimidinones using Cerium chloride hepta hydrate as a catalyst from an aldehyde, β -keto ester and urea in ethanol is described. Compared to the classical Biginelli reaction conditions, this new method consistently has the advantage of good yields (56–97%).and its biological activity was determined by using Disc Diffusion method.

Keywords: Biginelli reaction; dihydropyrimidinones; cerium chloride heptahydrate; one-pot condensation; Anti microbialand Anti fungal Activity, Synthesis.


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