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Kalabharathi H L*, Sabreen Bashir, Mohammed Sibgatullah, Poornima R, Divya Reddy, Nagma Firdose


Aim: To evaluate Fluoxetine for its antidiuretic activity in albino wistar rats. Introduction: An intricate set of mechanisms sense, signal and modulate changes in plasma volume. Any abnormalities in this physiological system, resulting from various genetic or acquired disorders, including certain drugs can alter the normal homeostatic mechanisms. Diabetes insipidus is one such disease, caused by the inability to conserve water and maintain an optimum free water level. Anti diuretic drugs are required to treat this condition. Most of the available drugs need some amount of circulating ADH for their action. Hence there is need for the drugs which have ADH independent mechanisms for conservation of plasma osmolality. Materials & Methods: Albino wistar rats were divided into 3 groups containing 6 animals each. Standard group received vasopressin (4 units intraperitoneally), control group received distilled water (10ml/kg body weight) and test group received fluoxetine (4.5mg/kg body weight). The test drug was given for a period of five days. On fifth day diuresis was induced in all the groups of animals by giving frusemide(20mg/kg body weight). Urine volume and electrolyte concentration was measured at the end of 5 hour observation period. Results & Discussion: The results suggested no significant anti diuretic activity of the test drug fluoxetine. Further tests are required to evaluate the antidiuretic activity of fluoxetine in humans if any.

Keywords: Fluoxetine, Anti diuretic, diuretic cage.

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