Abstract

STUDIES ON ANTIMICROBIAL POTENTIAL OF NEW ISATIN DERIVATIVES

Amit Saxena, Saurabh Sharma, Asif Husain*

ABSTRACT

In a present investigation, a series of new isatin derivatives (3a-i) were prepared by condensing substituted isatins with benzoyl hydrazides. The structures of the synthesized compounds were established on the basis of modern analytical techniques. The title compounds were evaluated for antimicrobial activity against some selected gram (+) gram (-) bacterial strains, and fungal strains. Preliminary screening was carried out for all the compounds and potent compounds were further evaluated for MIC. Anti-tubercular activity was also determined by MABA against Mycobacterium tuberculosis strain H37Rv. The findings are interesting and show that the compounds are biologically active.

Keywords: Oxindole, hydrazide, antibacterial, antifungal, antitubercular activity.