Abstract

Ambroxol, Hydroxy propyl methylcellulose (HPMC), Polyvinyl pyrrolidone (PVP), Spray drying, Taste masking.

*Kundlik Girhepunje¹, Vishal Lokhande², Ranju Pal²

ABSTRACT

Various plant gums like gelatin, acacia, alginic acid, guar gum etc. have been used as binder in pharmaceutical formulations. But still finding novel binder are useful in the pharmaceutical industry for manufacture of tablets and capsules. The Cassia tora seed gum was found for its binding property. The isolated gum was evaluated for its binding property like viscosity, % of fine and stability. The adhesive and cohesive property in tablet like hardness, friability, disintegration time and dissolution rate were evaluated on paracetamol tablets. All evaluation were compared with widely used standard sodium carboxy methyl cellulose and gelatin. The gum was prepared from seeds of Cassia tora and the prepared gum was evaluated for viscosity using different concentration like 1%, 1.5% and 2% which compared with the same concentration of sodium CMC and gelatin. The Cassia tora seed gum was found to be more viscous than sodium CMC and gelatin. which also produce less fine. Only the marginal difference was found in the hardness of tablet when compared with standard sodium CMC and gelatin. It also showed linearity between concentration and hardness. Increased concentration of Cassia tora seed gum from 2 to 6% increased the disintegration and dissolution time. Cassia tora gum produce tablet with better mechanical properties, longer disintegration and dissolution time than those containing sodium CMC and gelatin. This suggest that Cassia tora gum could be useful binding agent especially when high mechanical strength and slower release concern.

Keywords: Cassia tora, binder, tablet, sodium CMC, gelatin, drug release, stability.