Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS AUGUST ISSUE PUBLISHED
  • AUGUST 2020 Issue has been successfully launched on 1 August 2020.

Abstract

A PRELIMINARY REPORT ON ANTIHYPERGLYCEMIC AND ANALGESIC PROPERTIES OF METHANOL EXTRACT OF BRASSICA OLERACEA L. VAR. ITALICA SPROUTS

Md. Yousuf Hasan, Rahat Al- Mahamud, Shahnaz Rahman, Ishtiaq Ahmad, Mohammed Rahmatullah*

ABSTRACT

Background. Brassica oleracea var. italica (broccoli) is cultivated in Bangladesh for its edible sprout, which is known to be rich in several bio-active components and has therapeutic potential for treatment of cancer, diabetes and inflammatory diseases. It was of interest to determine the antihyperglycemic and analgesic properties of the sprouts of the plant. Methods. Antihyperglycemic activity was determined through oral glucose tolerance tests (OGTT). Analgesic activity was determined by observed decreases in abdominal constrictions (writhings) in intraperitoneally administered acetic acid-induced pain model in mice. Results. Administration of methanol extract of broccoli sprouts led to dose-dependent reductions in blood glucose levels in glucose-loaded mice. At doses of 50, 100, 200 and 400 mg per kg body weight, the extract reduced blood glucose levels by 12.9, 29.6, 35.9, and 40.4%, respectively compared to control animals. By comparison, a standard antihyperglycemic drug, glibenclamide, when administered at a dose of 10 mg per kg body weight, reduced blood glucose level by 45.6%. In analgesic activity tests, the extract at doses of 50, 100, 200 and 400 mg per kg body weight significantly and dose-dependently reduced the number of abdominal constrictions by 14.8, 29.6, 37.0, and 51.9%, respectively. A standard pain relieving (analgesic) drug, aspirin, reduced the number of writhings by 37.0 and 55.6%, respectively, when administered at doses of 200 and 400 mg per kg body weight. Conclusion. Broccoli sprouts can be beneficial in lowering blood glucose and for alleviating pain.

Keywords: Antihyperglycemic, Brassica oleracea, analgesic, Brassicaceae, broccoli


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More