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Keyur S. Patel 1*, Mandev B. Patel2

1Research Scholar, Bhagwant University, Ajmer, Rajasthan, India
2A-One Pharmacy College, Enasan, Ahemedabad, Gujarat, India.


The objective of present study was to develop Nicorandil controlled release microspheres by using PLGA. The Nicorandil loaded PLGA microspheres were formulated by solvent evaporation method. A 3 2 factorial design was employed to study the influence of drug: polymer ratio and Percentage Polyvinyl alcohol (PVA) concentration on Percentage Yield , Percentage Entrapment efficiency, Particle size and % In vitro drug release at 24 hrs. The Entrapment efficiency was found to be 21.33 ±2.75% to 43.32±1.24% and particle size range 12.09±1.01μm to 29.94±1.88μm. The Batch PL9 showed almost 100 % drug release after 7 days. Drug: Polymer ratio and Percentage PVA concentration had significant effect on % Yield, % Entrapment efficiency and Particle size. % In vitro drug release was decreased with increasing the drug: polymer ratio and decreasing the % PVA concentration. From the SEM study observed that microspheres were spherical and smooth surface. Anomalous (non-Fickian) diffusion was the mode of drug release from Nicorandil loaded PLGA microspheres formulations.

Keywords: Nicorandil, PLGA, Microspheres.

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