Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS AUGUST ISSUE PUBLISHED
  • AUGUST 2020 Issue has been successfully launched on 1 August 2020.

Abstract

PREPARATION AND CHARACTERIZATION OF NICORANDIL MICROSPHERES

Keyur S. Patel 1*, Mandev B. Patel2

1Research Scholar, Bhagwant University, Ajmer, Rajasthan, India
2A-One Pharmacy College, Enasan, Ahemedabad, Gujarat, India.

ABSTRACT

The objective of present study was to develop Nicorandil controlled release microspheres by using PLGA. The Nicorandil loaded PLGA microspheres were formulated by solvent evaporation method. A 3 2 factorial design was employed to study the influence of drug: polymer ratio and Percentage Polyvinyl alcohol (PVA) concentration on Percentage Yield , Percentage Entrapment efficiency, Particle size and % In vitro drug release at 24 hrs. The Entrapment efficiency was found to be 21.33 ±2.75% to 43.32±1.24% and particle size range 12.09±1.01μm to 29.94±1.88μm. The Batch PL9 showed almost 100 % drug release after 7 days. Drug: Polymer ratio and Percentage PVA concentration had significant effect on % Yield, % Entrapment efficiency and Particle size. % In vitro drug release was decreased with increasing the drug: polymer ratio and decreasing the % PVA concentration. From the SEM study observed that microspheres were spherical and smooth surface. Anomalous (non-Fickian) diffusion was the mode of drug release from Nicorandil loaded PLGA microspheres formulations.

Keywords: Nicorandil, PLGA, Microspheres.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More