Photo Gallery



News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • AUGUST 2020 Issue has been successfully launched on 1 August 2020.



*Ugbo Emmanuel, Ezaka Emmanuel, Orji Jerry, Moses Ikechukwu, Agumah Nnabuife, Nwachi Chinyere, Ogene Lilian, Okata-Nwali Divine, Ngwu Justina


The indiscriminate use of antibiotics contributes to the dissemination of multiple antibiotic resistances in bacterial pathogens in the community and hospital environment; and this development is of serious public health importance. This study was conducted to determine the incidence of Pseudomonas aeruginosa and Escherichia coli in certain clinical samples as well as to determine their susceptibility patterns to some commonly used antibiotics. The organisms were isolated using standard microbiological techniques and the antibiotic susceptibility study was determined using the Kirby-Bauer disc diffusion method as per the guidelines of Clinical Laboratory Standard Institute (CLSI). The result of this studies showed that most of the clinical isolates were highly resistant to amoxicillin and amoxycillin-clavulanic acid. It was also observed that these clinical isolates showed least resistance to gentamicin, ofloxacin, and ciprofloxacin. There was a significant difference (P≥ 0.05) in the percentage resistance patterns between the clinical isolates of P. aeruginosa and E. coli. Eleven isolates that were resistant to more than one antibiotic were subjected to plasmid curing using 1 % and 5 % sodium dodecyl sulphate (SDS). It was observed that at treatment with 1 % SDS, some of the isolates became resistant to more than one antibiotic. But when SDS was increased to 5 %, some of the isolates that were resistant became completely sensitive to all the antibiotics used. However, one of the P. aeruginosa that was initially sensitive to chloramphenicol became completely resistant at 5 % SDS and another isolate of P. aeruginosa that was initially sensitive to septrin, sparfloxacin and ciprofloxacin became completely resistant at 1 % and 5 % SDS. Conclusively, the clinical isolates of P. aeruginosa and E. coli used in this study were multiply resistant to some commonly used antibiotics; and the transfer of resistance gene amongst organisms could be responsible for the growing development and spread of resistance in this environment.

Keywords: Multiple antibiotic resistance, Pseudomonas aeruginosa, Escherichia coli, Plasmid curing, Antimicrobial susceptibility testing

[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More