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Abstract

FORMULATION AND EVALUATION OF COLON TARGETTED TABLETS OF IBUPROFEN USING THE COMBINATION OF MICROBIALLY TRIGGERED AND pH SENSITIVE POLYMERS

R. Sugi Pappa*, A. Helen Sonia, V. Jenila Jose Jancy, R.N. Regitha, D. Ajitha, S.Indira.

ABSTRACT

The objective of the study was to minimize the drug release in upper gastro intestinal tract and to target the drug to colon by using the principles of compression coating using pH sensitive polymer, Eudragit L 100 over the core tablet of ibuprofen containing time dependent polymer (Ethyl cellulose) and microbially degradable polymer (xanthan gum) and the combination of both. 9 different batches were formulated i.e. F1 to F9. In F1,F2& F3 formulations 20, 30, and 40% of xanthan gum were used. In F4, F5& F6 formulations 20, 30, and 40% of ethyl cellulose were used. In F7, F8& F9 formulations 1:1, 1:3 & 3:1 ratios of ethyl cellulose and xanthan gum were used in combinations. Tablets were evaluated for their physicochemical properties and all the values were found within the limits. In-vitro drug release studies were done with and without human fecal content and drug release kinetic studies were also performed. The F3 formulation which contains 40% of xanthan gum shows 99.08% of drug release in the 21st hour in simulated colonic pH with human fecal content. From the kinetic studies it was observed that the formulation F3 follows super case II type of release and the rate of release is independent of the concentration. It was concluded that the polymer xanthan gum at 40% is effective than ethyl cellulose for colonic delivery of Ibuprofen.

Keywords: Colon targeting, Ibuprofen, Ethyl cellulose, Eudragit L 100, Xanthan gum.


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