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Abstract

FORMULATION AND EVALUATION OF IMMEDIATE RELEASE TABLETS OF ISONIAZID AND PYRIDOXINE HYDROCHLORIDE

Debjyoti Nag, Sudipta Das* and Arnab Samanta

ABSTRACT

The objective of the present study was to formulate and evaluate the Isoniazid (INH) and Pyridoxine HCl (Vitamin B6) immediate release tablets. The tablets were prepared by wet granulation technique using excipients such microcrystalline cellulose (MCC), starch, magnesium stearate and talc. DSC study shows there was no interaction between drug and excipients. The granules were evaluated by determining the angle of repose, bulk density, tapped density, Hausner ratio and Carr’s index. The angle of repose was found to be between 22.89º±0.45º to 29.41º±1.40º. The value of Carr’s index, Hausner ratio and the angle of repose of the granules showed good flow properties. The tablets were subjected to measurement of weight variation (within limit), drug content (97.56±0.13% to 101.16±0.14% for INH and 97.26±0.22% to 97.26±0.22% for Vitamin B6) hardness (5.666±0.60 to 7.666±0.68 kg/cm2), friability (less than 1%), disintegration time (6.21±0.42 to 16.48±1.11 minutes) and in-vitro release studies. The tablets were evaluated by simultaneous UV spectrophotometric method.In-vitro release profile indicates that formulation F2 and F7 gives most promising results, but formulation F7 showed minimum disintegration time and dissolution studies conclude that the more than 80% of drug was released within 15 minutes which is a desired criteria for immediate Release dosage form. The results also showed different parameters of stability studies of final batch (F7).

Keywords: Isoniazid, Pyridoxine HCl, Simultaneous UV spectrophotometric method, immediate release.


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