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Abstract

HYPOLIPEDEMIC EFFECT OF VARIOUS EXTRACTS OF WHOLE PLANT OF CALYCOPTERIS FLORIBUNDA (LAM) IN RAT FED WITH HIGH FAT DIET

Bhuvaneswari Santharam*, Ganesh P, Soranam R and Packia Lekshmi N.C.J.

ABSTRACT

Objective: The present study was designed to investigate the hypolipidemic activity of various extracts of whole plant of Calycopteris floribunda in High Fed Diet induced male wistar rats and to compare it with a standard hypolipidemic drug Atrovastatin. Methods: Adult male wistar rats of six numbers in each group were undertaken for study and also evaluated. Group I served as normal control, Group II received HFD, Group III received HFD along with petroleum ether extract of C. floribunda, Group IV received HFD along with ethyl acetate extract of C. floribunda, Group V received HFD along with methanolic extract of C. floribunda, Group VI received HFD along with standard drug Atrovastatin. Blood and tissues like liver, heart, aorta was examined for lipid profile. Results: In Group II animals (HFD) showed significant (P < 0.001) elevation in plasma and LDL – cholesterol, triglycerides, phospholipids and atherogenic index when compared to that of normal rat. Administration of ethyl acetate extract of C. floribunda at the dose of 200 mg / kg b.wt / day p.o along with high fat diet significantly (P < 0.001) prevented the rise in the above mentioned biochemical parameters with significant rise in the level of HDL – cholesterol than that of the other two extracts. Conclusion: The result suggests that ethyl acetate of C. floribunda extended protection against various biochemical changes in blood and tissues which have therapeutic potential for the treatment of hyperlipidemia, since they are able to improve lipid metabolism and are relatively safe for use in clinical conditions associated atherosclerosis.

Keywords: Calycopteris floribunda, Hypolipedemic effect, High Fat Diet, Rats, HDL.


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