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Abstract

EXPERIMENTAL STUDY TO DETERMINE THE EFFECT OF C.M.I & H.I. IN SELECTED DRUGS OF KUSHTAGHNA DASHEMANI IN PARTHENIUM INDUCED ANIMAL MODEL

Darshan Babu N*, Pampanna Gouda H, Umapati C. Baragi, Shrikanth P.H, B. Ravishankar

ABSTRACT

Background: Integumentary system which includes skin, the largest organ of the body, accounting for 16% to 20% of the total body weight. The structure of human skin is complete, consisting of a number of layers and tissue components with many important factors. Though it is a protective barrier between the body and external environment, it is easily exposed to infection. In environment we get a noxious weed called Parthenium which is known for its Allergic potentials like skin irritation. In classics, the description of tvak its layers & disease pertaining to each layer has been explained. Kushta (skin disorder) is a disease in which tvak (skin) is the vyakta sthana (place) & shotha (swelling) is exhibited as a general symptom. In classics it is explained that contact of poisonous herbs is a causative factor for agantuja (exogenous) shotha. So experimental study was carried out to evaluate the Kusthaghna property of kushtaghna dashemani in parthenium induced dermatitis. Aims & Objectives: 1) To study the effect of selected dravyas of Kushtaghna dashemani in parthenium induced dermatitis. 2) To assess Humoral and Cell mediate immunity. Materials & Methods: Wistar strain albino rats of either sex were selected, rats were randomly placed under 4 groups. Two control groups divided into parthenium control & cyclophosphamide control & other two are test group i.e. TED & 2 x TED dose of drugs were administered. Minimum of 6 rats were included in each group. Conclusion: The study showed that the parthenium extract with adjuvant elicits immunological oedema in pre-sensitized animals indicating CMI eliciting effect. Kushtaghna Dashemani drugs showed the better activity in CMI and immunosuppressant activity in humoral immunity.

Keywords: Parthenium, Humoral & Cell Mediate Immunity, Kushtaghna Dashemani etc.


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