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  • SEPTEMBER 2021 Issue has been successfully launched on 1 September 2021.

Abstract

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF CHALCONES AND PYRIMIDINES FROM 4- IMIDAZOLE-1-YL-ACETOPHENONE

Yerragunta Vishwanadham*, Kumaraswamy. T  and Dokala. Appaji

ABSTRACT

Chalcones are 1,3-diphenyl-2-propene-1-one, in which two aromatic rings are linked by a three carbon -unsaturated carbonyl system. Pyrimidines are one of the important heterocyclic compounds with various biological activites. In this view, it was proposed to synthesize some novel pyrimidines from chalcones. Chalcones are prepared by treating 4-imidazole-1-yl-acetophenone with different aromatic aldehydes. These chalcones on condensation with guanidine HCl and KOH gave 4-(4-(1H –imidazole-l-yl)-pyrimidin-2-amine derivatives. They have been screened for their antibacterial activity against Gram positive bacteria B.subtillis & B.pumilus and gram negative bacteria E.coli & P.vulgaris and antifungal activity against A.niger & P.crysogenium.

Keywords: Chalcones, pyramidines, 4- imidazole-1-yl-acetophenone, 4-(4-(1H –imidazole-l-yl)-pyrimidin-2-amine.


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