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Abstract

PEANUT OIL AS A LOW DENSITY MATERIAL IN THE FORMULATION OF FLOATING BEADS OF RANITIDINE HYDROCHLORIDE

Ramadevi K.*, Swarupa K., Chandra Sekhara Rao G.

ABSTRACT

The objective of this investigation is to develop a multi-unit gastroretentive sustained release dosage form of a water soluble drug, Ranitidine hydrochloride, which could cure peptic ulcer more efficiently by releasing the drug specifically in stomach for a prolonged duration of time. A new emulsion gelation technique was used to prepare emulsion gel beads using sodium alginate as the polymer. The gel beads containing peanut oil were prepared by gently mixing or homogenizing oil and water phase containing sodium alginate, which was then extruded in to calcium chloride solution. A total of 12 formulations were designed in the present work. The use of sodium alginate and combinations of sodium alginate and polymers like hydroxyethyl cellulose and polyvinyl pyrrolidone were used to study the effect on the sustaining property of the formed beads. It was found that sodium alginate was not sufficient to sustain the drug release at gastric pH. Appropriate combination of alginate and polymers could provide the sustain release of drug. F12 was found to be the best formulation with drug release of 98.50% within 12 hours.

Keywords: Oil-entrapped floating beads, sodium alginate, Ranitidine hydrochloride.


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