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Abstract

SIMULTANEOUS ESTIMATION OF IBUPROFEN AND CHLORZOXAZONE IN PURE AND ITS TABLET PREPARATION BY RP-HPLC METHOD

S. Neelima* and B. Thangabalan

ABSTRACT

A simple, rapid, reverse - phase high performance liquid chromatographic method has been developed and validated for the simultaneous estimation of Ibuprofen and Chlorzoxazone in pure and in tablet dosage form. The estimation was carried out on a Enable C18G (250 mm x 4.6mm i.d., particle size 5μm) column with a mixture of Acetonitrile:0.1% Ortho phosphoric acid in the ratio of 50:50 (v/v) as mobile phase. UV detection was performed at 270 nm. The method was validated for linearity, accuracy, precision, specificity and sensitivity as per ICH guidelines. The developed and validated method was successfully used for the quantitative analysis of commercially available tablet dosage form. The retention time was 2.51 and 5.83 min for Ibuprofen and Chlorzoxazone, respectively. The flow rate was 1.0 mL/min. The calibration curve was linear over the concentration range of 8-128 μg/mL for Ibuprofen and 10-160μg/mL for Chlorzoxazone. The LOD and LOQ values were found to be 0.0328 and 0.0429 μg/ml for Ibuprofen and 0.0994 and 0.1301 μg/ml for Chlorzoxazone, respectively. The high percentage of recovery and low coefficient of variance confirm the suitability of the method for the simultaneous estimation of Ibuprofen and Chlorzoxazone in pure and in tablet dosage form.

Keywords: Ibuprofen; Chlorzoxazone; RP-HPLC; Validation.


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