WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

  • WJPPS: APRIL ISSUE PUBLISHED
  • April Issue has been successfully launched on 1 April 2024.

Abstract

DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR NEVIRAPINE TABLET DOSAGE FORM

Vedigounder Murugan*, Ravindra Vishal Singh, Pavan Kumar Puvvada, Geetha Mukundan Manisha Shukla, and Ashwini A. Kulkarni.

ABSTRACT

A simple, rapid, precise and sensitive R-HPLC method for analysis of bulk drugs nevirapine and its degraded compounds has been developed. The method has been validated for the estimation of bulk drugs. Chromatography was carried out using C18 column having 25 cm × 4.6 mm internal diameter and 5μ particle size. The mobile phases include 70:30 (v/v) acetonitrile: ammonium acetate buffer respectively, pH was adjusted to 4 ± 0.1 with 5% orthophosphoric acid and glacial acidic acid. The flow rate was 1 ml/min. λ max for the drug was 223 nm by UV. The retention time for the drugs was 3.1 min. The method developed was validated in accordance with ICH guidelines and it was reproducible. The linearity range was 20-100 μg/ml for the drug. The LOD and LOQ was 0.25 ng/ml and 0.76 ng/ml respectively. The high recovery and low coefficients of variation confirm the suitability of this method for analysis of the above drug. A acid hydrolysis, alkali hydrolysis, oxidative stress and water stress degraded compounds identified and analyzed by this method.

Keywords: Nevirapine, method validation, forced degradation, RP-HPLC.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More