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Abstract

FORMULATION AND EVALUATION OF SALBUTAMOL TRANSDERMAL MEMBRANES USING POLYETHYLENE GLYCOL AS PERMEATION ENHANCER

Sam Johnson Udaya Chander J.*, Akelesh T, Ardra A, Misariya Sidheek T, Noufal VP, Venkatanarayanan R

ABSTRACT

Salbutamol is a beta2-adrenergic receptor agonist, which is used as an anti-asthmatic drug. The objective of the present study is to incorporate Salbutamol in the transdermal drug delivery system using polyethylene glycol as permeation enhancer and as plasticizer. The placebo and medicated films were evaluated for physiochemical properties and the medicated films were evaluated for uniformity of drug content, area variation and percent cumulative drug release. The in-vitro release study was performed using Franz diffusion cell. The patches were found to be thin and smooth and the permeation followed zero order kinetics. The release pattern of the drug extends up to 12 hours with 79% cumulative drug release, which entails this product with sustained drug release characteristic and this can minimize the frequent administration of conventional salbutamol dosage form. The medicated films also went through primary skin irritation test and the results showed that the films were non-irritant.

Keywords: Salbutamol, HPMC, polyethylene glycol, Franz diffusion cell.


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