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Raju DSSK, Kiranmayi Patnala* and Divya Rupa PV


Anemia is one of the major medical complications in Chronic Kidney Disease (CKD) and leads to cardio vascular complications like Left Ventricular Hypertrophy. Anemia in CKD patients is due to different causative factors, of which the most common factor is inadequate erythropoietin production, accompanied by iron deficiency. The present study comprises of 113 patients with evidence of CKD and in all individuals complete blood analysis and blood smear was examined. Serum sample of control and cases were used for estimation of serum iron, total iron binding capacity (TIBC) and ferritin. There is a significant decrease in red blood cell count, Hemoglobin, Hematocrit and haematimetric indices in both nondialysis and hemodialysis CKD patients. The iron profile in nondialysis group showed decreased serum iron and transferrin saturation (TSAT%) and increased TIBC and serum ferritin. In hemodialysis group serum iron and TIBC decreased and serum ferritin is raised. The hemodialysis group was further classified based on serum ferritin into two groups and there is a decrease of TIBC and increased TSAT% registered in the group with severely raised ferritin (>800 to 2000 ng/dl) than the group with moderately raised ferritin (>200 to <800ng/dl). Finally, peripheral smear in CKD showed most of cases to be microcytic hypochromic anemia. All the data suggested that there is severe anemia which is further aggravated as CKD progress. The corrected measures will improve the patients health and it also prevents the cardiovascular complications.

Keywords: Chronic Kidney Disease, Left Ventricular Hypertrophy, Anemia, Hemodialysis.

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