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Abstract

ANTIBACTERIAL AND ANTIFUNGAL STUDIES OF 5- ISOPROPOXYCARBONYL-4-ARYL-6-METHYL-3, 4-DIHYDROPYRIMIDIN-2(1H)-THIONES

S. Chitra* and D.Devanathan

ABSTRACT

Seven 5-isopropoxycarbonyl-4-aryl- -6-methyl-3,4-dihydropyrimidin-2(1H)-ones 4ag are screened for their antibacterial activity against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella typhi and antifungal activity against Candida albicans, Aspergillus flavus, Rhizopus and Mucor. Ciprofloxacin is used for the standard for antibacterial and Amphotericin B is used for the standard for antifungal studies. Compounds 4b, 4c, 4f and 4g exhibited excellent in vitro antibacterial activity against all the tested organisms. Whereas the same set of compounds exerted potent in vitro antifungal activity against Candida albicans, Aspergillus flavus and Rhizopus.

Keywords: Antibacterial activity, antifungal activity, Dihydropyrimidinones, Ciprofloxacin, Amphotericin B.


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