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Abstract

ENHANCEMENT OF SOLUBILITY AND DISSOLUTION PROPERTIES OF OXCARBAZEPINE BY SOLID DISPERSION

Madhu Gudipati*, Prathibha Bharathi Chittem and Rama Rao Nadendla

ABSTRACT

The objective of present study was to enhance the dissolution rate of Oxcarbazepine (OXC) by using solid dispersion technique. Solid dispersions in water soluble carriers have attracted considerable interest as a means of improving the dissolution rate, and hence possibly bioavailability of a range of hydrophobic drugs. The poor solubility of Oxcarbazepine leads to poor dissolution and hence variation in bioavailability. Oxcarbazepine is an anticonvulsant drug, mainly used as an add-on or first line treatment in adults and children. Due to sudden onset of attack, it is necessary to formulate antiepileptics into such a delivery system, which provide immediate relief. In the present investigation solid dispersions (SD) were prepared by employing different grades of Sodium Starch Glycolate (SSG). They were prepared by physical mixing, solvent evaporation and kneading method in three different mass ratios 1:1, 1:3 and 1:5. Comparision of the methods was also investigated. Physicochemical characterisation of disperse systems was carried out using FTIR. Dissolution tests were conducted and evaluated on the basis of cumulative percentage drug release. The prepared solid dispersions were also evaluated for precompression parameters like angle of repose, bulk & tapped density, drug content, Carr’s index and Hausner’s ratio. Improved dissolution was observed in 1:5 ratio disperse system of kneading method compared to solvent evaporation and physical method. Physicochemical characterisation results suggested that OXC existed in amorphous form in all dispersion systems which show that dissolution can be enhanced.

Keywords: Dissolution, Oxcarbazepine (OXC), Sodium Starch Glycolate (SSG), Kneading method, Solvent evaporation, Physical mixing, Solid dispersions.


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