Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS: SEPTEMBER ISSUE PUBLISHED
  • SEPTEMBER 2021 Issue has been successfully launched on 1 September 2021.

Abstract

BULL’S EYE (IN-LAY) TABLET: FIXED DOSE COMBINATION OF GLIPIZIDE AND METFORMIN HYDROCHLORIDE BY STEAM GRANULATION TECHNIQUE

Dr. T. V. Rao* and N. Bhadramma

ABSTRACT

The main objective of the investigation was to design and development of the fixed dose combination of Glipizide and Metformin Hydrochloride in-lay tablets prepared by steam granulation technique. The prepared granules were evaluated for angle of repose, bulk density, carr‟s index and Hausner‟s ratio, results revealed that preparation of granules were found to be good flow properties and the tablets were evaluated for hardness, friability, thickness, % drug content and in vitro release studies. In-lay tablet comprises of glipizide immediate release layer formulated with neem gum as disintegrating agent and metformin hydrochloride for sustained release formulated with HPMC K4M and gums such as xanthum gum and guar gum in which SR layer surrounded by glipizide immediate release granules. The drug-excipient compatibility studies were conducted by FT-IR studies. The mechanism of drug release from glipizide IR layer follows first order kinetics and zero order kinetic observed for metformin hydrochloride SR layer and the stability studies were performed as per ICH guide lines for formulated F9 and results obtained found to be stable.

Keywords: Metformin hydrochloride, Glipizide, Guar gum, Xanthum gum.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More