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Abstract

ENUMERATING THE ANTIOXIDANT POTENTIAL AND IN VITRO RADICAL SCAVENGING ACTIVITY OF THE ETHANOLIC ROOT EXTRACT OF OPERCULINA TURPETHUM

Veena Sharma*1, Manu Singh2

*1Department of Bioscience and Biotechnology, Banasthali University, Banasthali 304022, Rajasthan, India.
2Department of Bioscience and Biotechnology, Banasthali University, Banasthali 304022, Rajasthan, India.

ABSTRACT

The aim of present study was to investigate the antioxidant activities of roots of Operculina turpethum against free radicals. The potentially reactive derivatives of oxygen, as reactive oxygen species such as O2 ●-, H2O2 - and OH●- are generated inside the human body as a consequence of relevation to a surfeit of exogenous chemicals and a number of endogenous metabolic processes concerning redox enzymes and bioenergetic electron transfer. This oxidative smash up is a decisive etiological factor implicated in numerous persistent human diseases such as diabetes mellitus, cancer, atherosclerosis, arthritis, neurodegenerative diseases and also in the aging process. Based on growing attention in free radical biology and the lack of efficient therapies for most chronic diseases, the utility of antioxidants in fortification against these diseases is warranted.The specific in vitro standard procedures including DPPH (1,1-diphenyl-2-picryl-hydrazil), FTC(Ferric thiocyanate method) ,TBA (Thiobarbituric acid test) and metal chelating activity were performed.Data is expressed as mean SEM. A one-way analysis of variance (ANNOVA) was used to analyze the data.The results of the assay were then compared with natural antioxidants ascorbic acid, quercetin, EDTA and BHA (butylatedhydroxyanisole). On the basis of present study the extract showed considerable significance (p<0.01) as compared to standards. Our study suggested that this plant is a potential source of natural antioxidants that could serve as free radical inhibitor or scavenger thereby reducing the risk of various severe disorders including cancer.

Keywords: Antioxidant, DPPH, EDTA, Free radical, Operculina turpethum.


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