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  • SEPTEMBER 2021 Issue has been successfully launched on 1 September 2021.

Abstract

ANALYTICAL TECHNIQUES FOR THE ESTIMATION OF LAFUTIDINE IN BULK AND PHARMACEUTICAL DOSAGE FORMS: A REVIEW

C. Divya Bharathi*, G. Rammohanreddy, A.Ajitha, V.Uma Maheswara Rao

ABSTRACT

Lafutidine is second generation histamine H2 -receptor antagonist which inhibits gastric acid secretion. It is used for the treatment and prophylaxis of gastric and duodenal ulcers. It is also used for gastric mucosal lesion due to its gastro protective action and in pre-anesthetic medication. Chemically Lafutidine is 2-[(2-furylmethyl)sulfinyl]-N-((2Z)-4-{[4-(piperidin-1-ylmethyl)pyridin-2-yl] oxy } but – 2 – en – 1 – y l ) acetamide. Its empirical formula is C22H29N3O4S. Its absorption does not depend on presence of food in stomach and binds to plasma proteins (approx. 88%) at therapeutic concentration. Its metabolism occurs in liver by microsomal enzyme CYP3A4 (mainly) and CYP2D6 and its major metabolites are hydroxylatedLafutidine and SulfonylLafutidine. Literature survey reveals that Lafutidine is estimated individually by uv spectrometry, RP-UPLC, RP-HPLC, LC-ESI/MS, Stability indicating determination of process related impurities by UPLC, HPTLC-Densitometrio.

Keywords: Lafutidine, RP-HPLC, LC-ESI /MS.UV Spectrometric, RP-UPLC, HPLC- Denstitometrio.


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