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  • WJPPS: SEPTEMBER ISSUE PUBLISHED
  • SEPTEMBER 2021 Issue has been successfully launched on 1 September 2021.

Abstract

ANALYTICAL TECHNIQUES FOR THE ESTIMATION OF DUTASTERIDE IN BULK AND PHARMACEUTICAL DOSAGE FORMS: A REVIEW

A.Prateep Reddy*, K.Shilpa, A.Ajitha, V.Uma Maheswara Rao

ABSTRACT

Dutasteride (DTS), selective inhibitor of both,type 1 and type 2 isoforms of 5α-reductase (5-AR) enzyme that converts testosterone to 5α-dihydrotestosterone (DHT) which is responsible for enlargement of prostate, is used in treatment of benign prostatic hyperplasia, frequently occurring in men over the age of 50 years. Chemically, DTS is (5α,17β)-N-{2,5 bis (trifluoromethyl) phenyl}-3-oxo-4-azaandrost-1-ene-17-carboxamide with an empirical formula C27H30F6N2O2, representing a molecular weight of 528.5 g/mol. Literature survey reveals that Dutasteride is estimated individually by Spectrometric, RP-HPLC, LC/MS/MS, Stability indicating TLC & HPTLC, Surfactant, ionoc liquid two-phase system Extraction Coupled with Spectroflurometry.

Keywords: Dutasteride, RP-HPLC, LC/MS/MS, Spectrometric, Spectroflurometry, TLC, HPTLC.


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