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  • WJPPS: SEPTEMBER ISSUE PUBLISHED
  • SEPTEMBER 2021 Issue has been successfully launched on 1 September 2021.

Abstract

PREPARATION AND CHARACTERIZATION OF TWO STARCH DERIVATIVES AND THEIR EVALUATION AS TABLET DISINTEGRANTS

Dr. Ebtsam M. Abdou*

ABSTRACT

Purpose: This study aims to prepare new starch derivatives which are starch-phosphate (SP) and starch-urea-citrat (SUC) using chemical reactions and their evaluation as tablet disintegrants. Methods: the two starch derivatives were prepared through chemical reaction which was confirmed through IR and DSC analysis then they were evaluated for their physicochemical characters such as pH, solubility, hydration and swelling ability in addition to their compressibility characters in comparison to native starch. The two derivatives were tested for their disintegrating effect in direct compressed tablets using atenolol as model drug. The tablets were tested for their hardness, friability, wetting time, disintegrating time, and dissolution profile. Results: the chemical reactions used were confirmed through the DSC and IR analysis. The two derivatives have better physicochemical properties compared to the native starch especially their compressibility characters which facilitate their use in direct-compressed tablets. The disintegrating effect of SP and SUC was indicated in the disintegrating time (ranged from 19±4 to 63±5 s) and wetting time (ranged from 61±2 to 122±5 s) of the prepared tablets, they showed good disintegrating effect. Conclusion: The two starch derivatives showed promising tablet disintegrating effect.

Keywords: Tablet-disintegration-starch urea citrat- starch phosphate-wetting-dissolution.


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