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Abstract

FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF LEVOCETIRIZINE DIHYDROCHLORIDE USING NATURAL SUPERDISINTEGRANTS

Rayaprolu. Mounica 1*, Voleti. Vijaya kumar1, Vedachalam. Gunasekharan1

Department of Pharmaceutics, Rao’s College of Pharmacy, Nellore, A. P, India.

ABSTRACT

The purpose of the work is an attempt to made formulation and evaluation of fast dissolving tablets of Levocetirizine dihydrochloride by direct compression method with the aid of natural superdisintegrant addition. Orally disintegrating tablets offers a solution for those have difficulty in swallowing tablets/capsules resulting in improved patient compliance. Fast dissolving tablets of Levocetirizine dihydrochloride were prepared by direct compression using orange peel pectin and Plantago ovata mucilage and as superdisintegrants. Ten formulations F1 to F10 were developed in such a way that total weight of the tablet remains the same. The optimised formula (F10) was again prepared by wet granulation method and dissolution profiles of both (F10 & F10w) were compared. All the formulated tablets were subjected for pre and post-compression evaluation parameters. Among ten formulations F10 showed highest drug release of 99.12% than other formulations. Accelerated stability studies for F10 was performed.

Keywords: Levocetirizine dihydrochloride, Direct compression, Orange peel pectin, Plantago ovata mucilage.


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