Abstract

DESIGN AND EVALUATION OF SUSTAINED RELEASE FLOATING MATRIX TABLETS OF AMOXICILLIN TRIHYDRATE

Pramoda.G, Ashok Kumar.P*, Bhoopathi.G.S,Vijaya Durga.K, Suresh V.Kulakarni

Sree Siddaganga College Of Pharmacy,B.H.Road,Tumkur-572102,Karnataka,India.

ABSTRACT

Gastro retentive drug delivery systems of Amoxicillin trihydrate as floating tablets were prepared with the impartial to obtain site-specific drug delivery and to extend its duration of action. More over the floating system of amoxicillin will provide improved local and systemic action in stomach. The formulations were prepared as floating matrix tablets. The drug and polymers were found to be compatible as seen by IR studies. Tablets were prepared by direct compression technique. The prepared tablets were evaluated for weight variation, hardness, friability, drug content, buoyancy and in-vitro dissolution studies. Optimized formulation of F-9 amoxicillin was found to have increased gastric residence prolonging the release of drug with 98.5% of drug release in 12 hours in vitro. The release mechanisms were explored and explained with zero order, first order, Higuchi and Korsmeyer equations. The mechanism of drug release from optimized formulation F-9 was found to be anomalous(non-Fickian)diffusion and followed zero order kinetics. Hence gastro retentive drug delivery system of Amoxicillin trihydrate is a promising approach as it can lead to decrease in the frequency of administration and eventually lead to better patient compliance.

Keywords: Gastro retentive; amoxicillin; buoyancy; zero order.