Abstract

PREPARATION AND EVALUATION OF POLY CAPROLACTONE COMPOSITE MICROPARTICLES BY W/O/W EMULSION METHOD

Department of Pharmaceutical Science, Saurashtra University, Rajkot, India.

ABSTRACT

The drug as Theophylline from Xanthine Derivative is still widely used as an effective bronchodilator in the disease of Asthma .Theophylline is used as a prophylactic drugs and to prevent acute exacerbations of asthma also. The aim of study that to find out the drug release in different dosage forms and find out the different burst effect in different dosage forms. So, here we prepare the different batches of different dosage forms like drug containing microparticles, Blank microparticles, Drug containing Nano particles, Blank Nanoparticles, Blank Composite Microparticles and Drug containing the Composite microparticles. Furthermore Double Emulsion Solvent Evaporation Method(W1/O/W2) was used to prepare these all type of dosage forms. The prepared Polycaprolactone composite microparticles was characterized by % Yield , Particle size analysis, Zeta Potential, drug loading efficiency, X ray diffraction study and scanning Electron Microscopy. The different types of ratio of polymers to drugs are used. Due to all above characterization study we find out the optimum polymers to drug ratio and reduced the burst effect also. We used the polycaprolactone and Ethylcellulose as the polymers to find out the result also.

Keywords: Burst Effects, Composite Microparticles, Nano particles, Microparticles, Polycaprolactone.