FORMULATION AND EVALUATION OF MATRIX TABLETS FOR COLON SPECIFIC DELIVERY OF MEBENDAZOLE
Mahantesh G. Kavatekar*, Chandrashekar C. Patil, Raghavendra V. Kulkarni,
Ajay S. Shahapur, Santosh B. Girani and Baburao N. Chandkavathe.
ABSTRACT
In the present study, an attempt was made to prepare and evaluate natural polymers based matrix tablets of Pectin, Xanthan gum and guar gum & their combination for colon targeted delivery of Mebendazole. The matrix tablets were prepared by wet granulation method. The weight and drug contents of all tablets were found to be uniform with low SD values. The hardness & friability were within specified range. The DSC & FTIR study indicated that the drug is stable in the formulations. The in-vitro drug release study was performed using dissolution rate test apparatus in gastric and intestinal fluids. The uncoated tablets failed to retard the drug release in the environment of stomach and small intestine; hence they are not suitable for colon targeted delivery of drug as maximum amount of drug was released in the physiological environment of stomach and small intestine within 5 hours. Whereas, tablets coated with Eudragit RS100 released small
amount of drug within 5 hours and maximum amount of drug was targeted to colonic region. Therefore Eudragit RS100 was found very effective in targeting drug to colon. The M2 tablet which showed satisfactory release in-vitro was tested for its integrity and transit in-vivo in rabbits. The results of in vivo roentgenography showed that the prepared tablet was intact up to 11 hours and transit was clearly seen. Drug release mechanism followed non-Fickian transport.
Keywords: Colon targeting, Mebendazole, Pectin, Guar gum, Eudragit RS-100, X - Ray study.
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