Abstract

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF NOVEL 2-CYCLIC AMINE BENZOXAZOLE DERIVATIVES

Gollapalli Naga Raju*, Tallapaneni S K T Prasanna, Medipalli Krishna Lakshmi Surekha, Martha Suneetha, Rama Rao Nadendla

ABSTRACT

A novel series of 2-(Cyclic amine)-1,3-benzoxazole derivatives were synthesized from the 2-chlorobenzoxazole was treated with various cyclic amines under microwave irradiation conditions in the presence of zinc dust. All the synthesized compounds have been characterized by using elemental analysis, FT-IR, 1H NMR, 13C NMR spectroscopy and further supported by mass spectroscopy. Purity of all the compounds has been checked on thin layer chromatographic plate and HPLC technique. All the synthesized compounds were tested for their antibacterial and antifungal activity (MIC) in vitro by broth dilution method with two Gram-positive bacteria, two Gram-negative bacteria and two fungal strains. The biological activities of the synthesized compounds have been compared with standard drugs Streptomycin and Amphotericin-B. . The compounds exhibited significant antibacterial and moderate antifungal activities. These compounds can be further exploited to get the potent lead compounds. The detailed synthesis and the antimicrobial screening of the new compounds are reported.

Keywords: Benzoxazole, Zinc dust, cyclic amines, Antibacterial activity, Antifungal activity.