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Abstract

PREVALENCE AND ANTIBIOGRAM OF ENTEROCOCCUS SPECIES IN A TERTIARY CARE HOSPITAL

Dr. Praveen Kumar Doddamani1, Dr. Srikanth*2, Dr. Nandini.T3, Dr. Rathai Rajagopalan4

1Department of Microbiology, Mediciti institute of medical sciences, Ghanpur village, Medchal Mandal, R.R district, Andhra Pradesh, 501401, India
2Department of Pharmacology, Khaja Banda Nawaz institute of medical sciences, Gulbarga, 585104, India
3Department of Pharmacology, Sri Siddhartha Medical College and Research Centre, Tumkur, 527 107, India
4Department of Pharmacology, M.S. Ramaiah Medical College, MSR Nagar, MSRIT Post, Bangalore, 560054, India.

ABSTRACT

Enterococci have emerged as one of the leading cause of nosocomial infections, and recently have been persisting clinical problem globally due to their resistance to antimicrobials. The aim of study was to estimate the prevalence and antibiogram of Enterococcus infection in a tertiary care hospital. This was a retrospective study conducted in a tertiary care hospital in south India in November 2012. The samples which were included were urine, pus, sputum, wound discharge, blood and body fluids which were collected aseptically and their culture and the antibiogram was done as per the standard recommendations. E. faecalis was the most common species isolated in all clinical specimens except in blood cultures where E. faecium was the most common isolate. Maximum cases were isolated from urine followed by pus and blood. The infection was polymicrobial in 50 (47.1%) patients. E.coli was the most common concomitant infection (14.1%) followed by Klebsiella (11.3%) and Staphylococcus aureus (10.3%). Maximum resistance was seen with Erythromycin and least with Teicoplanin and Linezolid. Resistance to Vancomycin in E. faecium was 11.7%, higher than E. faecalis (5.88%). Of the eight Vancomycin resistance isolates, three showed resistance to Teicoplanin, two for E. faecium and one for E. faecalis. All Enterococcus species were sensitive to Linezolid. The emergence of VRE is a cause of concern because of the limited therapeutic options for treating serious infections and because of their potential to transfer Vancomycin resistance genes to other organisms such as Methicillin-resistant Staphylococcus aureus. The most effective way to prevent resistance is to have an hospital antibiotic policy. The regular surveillance of Enterococci will help to know the changing trends of antibiotic susceptibility pattern and for selecting an appropriate antibiotic.

Keywords: Enterococci, Vancomycin resistant enterococci, Nosocomial infection.


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