WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

IMPACT OF DOXORUBICIN AND VITAMIN E, A SEPERATELY AND IN COMBINATION ON RAT TISSUES ORGANIC CONSTITUENTS

Vijayudu Bandela*, Harish Babu Kuruba, Venkatakrishnaiah Yakkluri, Rajeswara Rao Merugupala

ABSTRACT

The in vivo effect of 20 mg / kg weight of Dox, 100 mg / kg weight of vitamin E and 50 IU / kg weight of vitamin A separately and in combination over 10 weeks period (weekly doses), the state of rat tissues based organic constituents like total proteins, total carbohydrates total lipid, free amino acids, free fatty acids, glycogen and pyruvate, lactate and serum glucose levels were reported. The data indicated decreased total proteins, total carbohydrates total lipid, glycogen and pyruvate content followed by increased levels of free amino acids, free fatty acids, and serum glucose and lactate in all the rat tissues under Dox stress were observed. All these Dox altered rat tissues organic constituents appear to be neutralized by in the presence of Dox plus vitamin E and Dox plus vitamin A. From the result it is reported that Dox impair the overall general metabolism of rat tissues and the antioxidants like vitamin E and A by their antioxidant mechanism might be neutralizing the Dox altered rat tissues organic constituents in vivo.

Keywords: Doxorubicin, Vitamin E, Vitamin A, Organic Constituents, Albino Rat tissues.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More