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Abstract

EFFICACY OF METHANOL LEAF EXTRACT OF Pimento dioica (MYRTACEA) ON THE BLOOD GLUCOSE LEVEL AND LIPID PROFILE OF STREPTOZOTOCIN INDUCED DIABETIC ALBINO RATS

K. Yoga Lakshmi* and J. Vaidehi

ABSTRACT

The present study was designed to investigate the antidiabetic and
antihyperlipidemic activity of the methanolic extract of the leaves of
Pimento diocia in streptozotocin (STZ) induced diabetic rats. Diabetes
was induced in male albino wistar rats by single intraperitoneal
injection of STZ. Three days after STZ induction, the diabetic rats
were treated orally with P.dioica at the doses of 75mg/kg and 150
mg/kg of body weight daily for 45 days. Glibenclamide (0.6mg/kg of
body weight) was used as reference drug. Blood glucose estimation
was performed every week of the study. At the end of the study period,
animals were sacrificed for the measurement of fasting blood glucose,
total cholesterol (TC), triglyceride (TG), high density lipoprotein
(HDL), low density lipoprotein (LDL) and very low density lipoprotein
(VLDL). Significant reduction (P<0.005) in fasting blood glucose levels was observed with
increasing treatment durations. Thus the present study suggested significant antidiabetic and
antihyperlipidemic potential in the methanolic leaf extracts of P. dioica.

Keywords: Antidiabetic, antihyperlipidemic, Pimento dioica, glibenclamide.


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