Abstract

DEVELOPMENT AND EVALUATION OF CHITOSAN BASED ORAL CONTROLLED RELEASE MATRIX TABLETS OF PREGABALIN

Hansiya Sultana, Kiran Kumar G.B*, Ankit Acharya and Mohammed Gulzar Ahmed

ABSTRACT

The main aim of present work was to formulate and evaluate controlled release matrix tablets of pregabalin; an antiepileptic drug. Controlled release formulation is such drug delivery system that delivers the drug locally or systemically at a predetermined rate for a fixed period of time. The matrix tablet were prepared by direct compression method using by various concentration of chitosan with combination of various release retardant polymers like HPMC K100M, carbopol 934P, xanthan gum and trisodium citrate as cross-linking agent. Compatibility of the drug with the polymers was studied using Fourier transform infrared spectroscopy and result showed no possible interaction between drug and excipients. The powder mixtures were subjected to pre-compression studies and obtained results were found to be satisfactory. The compressed tablets were evaluated for postcompression parameters such as weight variation, hardness, drug content, swelling study, invitro drug release and stability studies. Swelling studies were carried out using water uptake method and results revealed that formulation F3 containing higher concentration of carbopol and chitosan showed highest swelling capacity. In-vitro dissolution studies were carried out for 24 hours using 0.06N HCL for first 2 hours and pH 6.8 phosphate buffer for remaining 22 hours. Formulation F3 was able to release 99.45% drug at the end of 24 hours. The release data were fitted to various mathematical models and it was found that formulation batches followed first order release kinetics indicating drug release was concentration dependent. Formulation F3 and F9 were subjected to short term stability studies and were physiochemically stable throughout the study period.

Keywords: Carbopol 934P, controlled release matrix tablet, Pregabalin, HPMC K100M, xanthan gum, chitosan.