Abstract

FLOATING DRUG DELIVERY SYSTEM A NOVEL APPROACH FOR GASTRO RETENTIVE DRUG DELIVERY

Omprakash G. Bhusnure*, Amol G.Marde and Chandrakant A. Shinde, Mr.Gholve SB, Thonte SS

ABSTRACT

In the recent years, scientific and technological advancements have been made in the research and development of novel drug delivery systems by overcoming physiological troubles such as short gastric residence times and unpredictable gastric emptying times. Several approaches are currently utilized in the prolongation of the gastric residence times, including floating drug delivery systems, swelling and expanding systems, polymeric bio adhesive systems, modified-shape systems, high-density systems and other delayed gastric emptying devices. It is known that differences in gastric physiology (such as, gastric pH, motility) exhibit both intra- as well as inter-subject variability demonstrating significant impact on gastric retention time and drug delivery behavior. The methodologies used in the development of FDDS by formulating effervescent and non effervescent floating tablets based on buoyancy mechanism. By utilizing above feasible approaches it is possible to deliver drugs which have narrow therapeutic window. Our review article is in pursuit of giving detailed information on the pharmaceutical basis of their design, classification, preparation, factors affecting on FDDS, advantages, applications, limitations and the future potential of FDDS.

Keywords: Floating Drug Delivery System, Gastric Residence Time, Effervescent, Non effervescent, and Gastro Retentive Dosage Form.