Abstract

FORMULATION AND EVALUATION OF FLOATING MATRIX TABLETS OF VALSARTAN USING PEANUT HUSK POWDER BY NON-EFFERVESCENT METHOD

Dr. A. Abdul Hasan Sathali* and S. Vanitha

ABSTRACT

The aim of the work is to modify the bioavailability of Valsartan, by employing non-effervescent floating drug delivery (tablet dosage forms). Non-effervescent systems are a type of floating drug delivery systems that have been used to boost the gastric residence and the floatation time in the gastrointestinal tract. The study included formulation of floating tablets using polymers like Hydroxy propyl methyl cellulose K15M, Hydroxy propyl methyl cellulose K100M, Sodium carboxy methyl cellulose and Eudragit RS100 as a matrix forming agents. Peanut husk powder was used as floating agent. The tablets were prepared by direct compression technique. FTIR and DSC-TGA studies conformed that there was no incompatibility between the polymers and the drug. Tablet preformulation parameters were within the Pharmacopoeias limit. Tablet showed zero lag time, continuance of buoyancy for >12 h. In vivo X-ray studies depicted that tablets continued to float in the GIT for 12 h. The in-vitro drug release pattern of Valsartan floating tablets was fitted to different kinetic models which showed highest regression for zero order kinetics with Koresmeyer-peppas& most of the formulations followed Non-fickian diffusion. Thus the prepared non-effervescent floating tablet of Valsartan can be used for the treatment of hypertension for more than 12 h with single dose administration.

Keywords: Floating drug delivery system, HPMC, Valsartan, Peanut husk powder, SCMC & Eudragit RS100.