Abstract

SYNTHESIS OF VARIOUS 3-(6-SUBSTITUTED-3-HYDROXY-2,2- DIMETHYL-3,4-DIHYDRO-2H-BENZOPYRAN-4-YL)-2- SUBSTITUTED-1,3-THIAZINAN-4-ONES FOR ANTIHYPERTENSIVE ACTIVITY

Soma Pramanik* and Amit Kumar Das

ABSTRACT

A series of 3-(6-substituted-3-hydroxy-2,2-dimethyl-3,4-dihydro-2hbenzopyran- 4-yl)-2-substituted-1,3-thiazinan-4-ones have been synthesized from 4-substituted phenols as starting material. Substituted phenols were first acylated with acetic acid in presence of Lewis acid to substituted acetophenones which then undergone fries rearrangement reaction, cyclisation, reduction, epoxidation, ring opening reaction, Schiff‟s reaction n reaction with thiolactic acid to synthesize various benzopyran derivatives with good yields. The structures of the synthesized compounds were established through 1HNMR, MASS and FT-IR spectral data. The synthesized compounds were screened for their in vivo antihypertensive activity using tail-cuff method in fructose-induced Albino Wistar rats.

Keywords: Benzopyrans, thiazinan-4-ones, antihypertensive activity, tail-cuff method.